Scientific Publications

Haijie Li, Lu Yin, Ni He, Peng Han, Yueqiang Zhu, Yue Ma, Aidi Liu, Hong Lu, Zhipeng Gao, Peifang Liu, Yaopan Wu, Zhaoxiang Ye, Comparison of comfort between cone beam breast computed tomography and digital mammography, European Journal of Radiology, Volume 120, 2019, 108674, ISSN 0720-048X, https://doi.org/10.1016/j.ejrad.2019.108674.

Abstract
Purpose: To compare the comfort levels of cone beam breast computed tomography (CBBCT) and digital mammography.

Lingcong Yang, Zijie Zhou, Jun Wang, Qiang Lin, Yahui Dong, Zhirong Guo, Fujun Shi. Eur J Radiol 2024 Jan 8:171:111292. doi: 10.1016/j.ejrad.2024.111292. PMID: 38211395

Abstract

Introduction: To compare the diagnostic performance of cone-beam breast computed tomography (CBBCT) and mammography (MG) in primary breast cancer.

O’Connell A, Conover DL, Zhang Y, Seifert P, Logan-Young W, Lin CF, Sahler L, Ning R. Cone-beam CT for breast imaging: Radiation dose, breast coverage, and image quality. AJR Am J Roentgenol. 2010 Aug;195(2):496-509. doi: 10.2214/AJR.08.1017. PMID: 20651210.

Abstract

This pilot study compared cone-beam breast CT to mammography regarding radiation dose, breast coverage, and image quality. Results showed similar radiation doses and detection of masses/calcifications between the two methods. Cone-beam breast CT provided better coverage in certain areas but poorer coverage in the axilla. The study concludes that cone-beam breast CT effectively images the entire breast with comparable radiation dose to mammography.

Yafei Wang, Mengran Zhao, Yue Ma, Aidi Liu, Yueqiang Zhu, Lu Yin, Zhiran Liang, Zhiye Qu, Hong Lu, Ying Ma, Zhaoxiang Ye, Accuracy of Preoperative Contrast-enhanced Cone Beam Breast CT in Assessment of Residual Tumor after Neoadjuvant Chemotherapy: A Comparative Study with Breast MRI, Academic Radiology, 2023

Abstract

Rationale and Objectives

To compare the accuracy of preoperative contrast-enhanced cone beam breast CT (CE-CBBCT) and MRI in assessment of residual tumor after neoadjuvant chemotherapy (NAC).

Wienbeck S, Fischer U, Luftner-Nagel S, Lotz J, Uhlig J. Contrast-enhanced cone-beam breast-CT (CBBCT): clinical performance compared to mammography and MRI. Eur Radiol. 2018 Sep;28(9):3731-3741. doi: 10.1007/s00330-018-5376-4. Epub 2018 Mar 28. PMID: 29594402.

Abstract

Objectives: To evaluate the diagnostic accuracy of contrast-enhanced (CE) cone-beam breast computed tomography (CBBCT) in dense breast tissue and compare it to non-contrast (NC) CBBCT, mammography (MG) and magnetic resonance imaging (MRI).

Zhu Y, O’Connell AM, Ma Y, Liu A, Li H, Zhang Y, Zhang X, Ye Z. Dedicated breast CT: state of the art-Part II. Clinical application and future outlook. Eur Radiol. 2022 Apr;32(4):2286-2300. doi: 10.1007/s00330-021-08178-0. Epub 2021 Sep 3. Erratum in: Eur Radiol. 2022 Feb 14;: PMID: 34476564.

Abstract

Dedicated breast CT is being increasingly used for breast imaging. This technique provides images with no compression, removal of tissue overlap, rapid acquisition, and available simultaneous assessment of microcalcifications and contrast enhancement. In this second installment in a 2-part review, the current status of clinical applications and ongoing efforts to develop new imaging systems are discussed, with particular emphasis on how to achieve optimized practice including lesion detection and characterization, response to therapy monitoring, density assessment, intervention, and implant evaluation. The potential for future screening with breast CT is also addressed. KEY POINTS:

American Journal of Roentgenology. 2017;208: 1154-1162. 10.2214/AJR.16.16760

Abstract

Objective: The feasibility of breast vacuum-assisted biopsy (VAB) guided by cone-beam CT (CBCT) was assessed. The initial clinical performance of CT-guided breast VAB was compared with that of established prone stereotactic VAB.

Uhlig J, Uhlig A, Biggemann L, Fischer U, Lotz J, Wienbeck S. Diagnostic accuracy of cone-beam breast computed tomography: a systematic review and diagnostic meta-analysis. Eur Radiol. 2019 Mar;29(3):1194-1202. doi: 10.1007/s00330-018-5711-9. Epub 2018 Sep 25. PMID: 30255249.

Abstract

Purpose: To review the published evidence on cone-beam breast computed tomography (CBBCT) and summarize its diagnostic accuracy for breast lesion assessment.

Zhu Y, O’Connell AM, Ma Y, Liu A, Li H, Zhang Y, Zhang X, Ye Z. Dedicated breast CT: state of the art-Part I. Historical evolution and technical aspects. Eur Radiol. 2022 Mar;32(3):1579-1589. doi: 10.1007/s00330-021-08179-z. Epub 2021 Aug 3. Erratum in: Eur Radiol. 2022 Jan 7;: PMID: 34342694.

Abstract

Dedicated breast CT is an emerging 3D isotropic imaging technology for breast, which overcomes the limitations of 2D compression mammography and limited angle tomosynthesis while providing some of the advantages of magnetic resonance imaging. This first installment in a 2-part review describes the evolution of dedicated breast CT beginning with a historical perspective and progressing to the present day. Moreover, it provides an overview of state-of-the-art technology. Particular emphasis is placed on technical limitations in scan protocol, radiation dose, breast coverage, patient comfort, and image artifact.

Ma Y, Liu A, Zhang Y, Zhu Y, Wang Y, Zhao M, Liang Z, Qu Z, Yin L, Lu H, Ye Z. Comparison of background parenchymal enhancement (BPE) on contrast-enhanced cone-beam breast CT (CE-CBBCT) and breast MRI. Eur Radiol. 2022 Aug;32(8):5773-5782. doi: 10.1007/s00330-022-08699-2. Epub 2022 Mar 23. PMID: 35320411.

Abstract

Objectives: To compare the background parenchymal enhancement (BPE) levels on contrast-enhanced cone-beam breast CT (CE-CBBCT) and MRI, evaluate inter-reader reliability, and analyze the relationship between clinical factors and BPE level on CE-CBBCT.

He N, Wu YP, Kong Y, Lv N, Huang ZM, Li S, Wang Y, Geng ZJ, Wu PH, Wei WD. The utility of breast cone-beam computed tomography, ultrasound, and digital mammography for detecting malignant breast tumors: A prospective study with 212 patients. Eur J Radiol. 2016 Feb;85(2):392-403. doi: 10.1016/j.ejrad.2015.11.029. Epub 2015 Nov 25. PMID: 26781145.

Abstract

Purpose: Breast cone-beam computed tomography (BCBCT) is a flat-panel detector (FPD)-based X-ray imaging system that provides high-quality images of the breast. The purpose of this study was to investigate the ability to detect breast abnormalities using non-contrast BCBCT and contrast-enhanced BCBCT (BCBCT and CE-BCBCT) compared to ultrasound (US) and digital mammography (MG).

Haijie Li, Lu Yin, Ni He, Peng Han, Yueqiang Zhu, Yue Ma, Aidi Liu, Hong Lu, Zhipeng Gao, Peifang Liu, Yaopan Wu, Zhaoxiang Ye, Comparison of comfort between cone beam breast computed tomography and digital mammography, European Journal of Radiology, Volume 120, 2019, 108674, ISSN 0720-048X, https://doi.org/10.1016/j.ejrad.2019.108674.

Abstract

Purpose: To compare the comfort levels of cone beam breast computed tomography (CBBCT) and digital mammography.

Zhao B, Zhang X, Cai W, Conover D, Ning R. Cone beam breast CT with multiplanar and three dimensional visualization in differentiating breast masses compared with mammography. Eur J Radiol. 2015 Jan;84(1):48-53. doi: 10.1016/j.ejrad.2014.05.032. Epub 2014 Jul 15. PMID: 25439008.

Abstract

Objective: This pilot study was to evaluate cone beam breast computed tomography (CBBCT) with multiplanar and three dimensional (3D) visualization in differentiating breast masses in comparison with two-view mammograms.

Vedantham S, Shi L, Glick SJ, Karellas A. Scaling-law for the energy dependence of anatomic power spectrum in dedicated breast CT. Med Phys. 2013 Jan;40(1):011901. doi: 10.1118/1.4769408. PMID: 23298092; PMCID: PMC3532103.

Abstract

Purpose: To determine the x-ray photon energy dependence of the anatomic power spectrum of the breast when imaged with dedicated breast computed tomography (CT).

Liu A, Ma Y, Yin L, Zhu Y, Lu H, Li H, Ye Z. Comparison of malignant calcification identification between breast cone-beam computed tomography and digital mammography. Acta Radiol. 2023 Mar;64(3):962-970. doi: 10.1177/02841851221112562. Epub 2022 Jul 11. PMID: 35815702.

Abstract

Background: Calcifications are important abnormal findings in breast imaging and help in the diagnosis of breast cancer. Purpose: To compare breast cone-beam computed tomography (CBCT) with digital mammography (DM) in terms of the ability to identify malignant calcifications.

Tseng HW, Karellas A, Vedantham S. Radiation dosimetry of a clinical prototype dedicated cone-beam breast CT system with offset detector. Med Phys. 2021 Mar;48(3):1079-1088. doi: 10.1002/mp.14688. Epub 2021 Jan 26. PMID: 33501686; PMCID: PMC9007273.

Abstract

Purpose: A clinical-prototype, dedicated, cone-beam breast computed tomography (CBBCT) system with offset detector is undergoing clinical evaluation at our institution. This study is to estimate the normalized glandular dose coefficients ( DgNCTDgNCT ) that provide air kerma-to-mean glandular dose conversion factors using Monte Carlo simulations.

Ma WM, Li J, Chen SG, Cai PQ, Chen S, Chen JT, Zhou CY, He N, Wu Y. Correlation between contrast-enhanced cone-beam breast computed tomography features and prognostic staging in breast cancer. Br J Radiol. 2022 Apr 1;95(1132):20210466. doi: 10.1259/bjr.20210466. Epub 2022 Jan 7. PMID: 34930038; PMCID: PMC9153710.

Abstract

Objective: To evaluate whether contrast-enhanced cone-beam breast CT (CE-CBBCT) features can risk-stratify prognostic stage in breast cancer.

H. Xie et al., “Deep Efficient End-to-End Reconstruction (DEER) Network for Few-View Breast CT Image Reconstruction,” in IEEE Access, vol. 8, pp. 196633-196646, 2020, doi: 10.1109/ACCESS.2020.3033795.

Abstract

Breast CT provides image volumes with isotropic resolution in high contrast, enabling detection of small calcification (down to a few hundred microns in size) and subtle density differences. Since breast is sensitive to x-ray radiation, dose reduction of breast CT is an important topic, and for this purpose, few-view scanning is a main approach.

Wienbeck, Susanne MDa,∗; Uhlig, Johannes MD, MPHa; Fischer, Uwe MDb; Hellriegel, Martin MDc; von Fintel, Eva MDa; Kulenkampff, Dietrich MDd; Surov, Alexey MDe; Lotz, Joachim MDa; Perske, Christina MDf. Breast lesion size assessment in mastectomy specimens: Correlation of cone-beam breast-CT, digital breast tomosynthesis and full-field digital mammography with histopathology. Medicine 98(37):p e17082, September 2019. | DOI: 10.1097/MD.0000000000017082

Abstract

To compare the accuracy of breast lesion size measurement of cone-beam breast-CT (CBBCT), digital breast tomosynthesis (DBT) and full-field digital mammography (FFDM).

Patients scheduled for mastectomy due to at least 1 malignant breast lesion were included. Mastectomy specimens were examined by CBBCT, DBT, FFDM, and histopathology.

Kang W, Zhong W, Su D. The cone-beam breast computed tomography characteristics of breast non-mass enhancement lesions. Acta Radiol. 2021 Oct;62(10):1298-1308. doi: 10.1177/0284185120963923. Epub 2020 Oct 18. PMID: 33070636.

Abstract

Background: Cone-beam computed tomography (CBBCT) of the breast is emerging as a way of improving breast cancer diagnostic yield.

Purpose: To find characteristics of non-mass enhancement (NME) lesions on breast CBBCT and to identify the characteristics that distinguish malignant and benign lesions.

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